I compiled a list of things I think burn people out.  Most of this is work related.

In no particular order...

Trying to appease others who don't really matter.

Trying to fit in with people who don't want things "different" because new is uncomfortable

AntonioGuillem

allowing yourself to get upset because other people say "no" because it's easiest.

Having to acknowledge whiny millennials (sense of entitlement)

Unclear expectations

Long hours

Long commute

Cleaning up other people's mess(es) who aren't around to be accountable